Zayn also scored number one in the UK and Ireland after releasing his first solo single on January 29.
It is just the 25th song ever to debut in first place on the Billboard Hot 100. Other UK stars achieving the coup include Adele with Hello and Elton John with Candle In The Wind.
Zayn tweeted his fans an incredulous thank you, giving them the credit for “making this all happen”.
But his number one was not the only thing he was proud of as he posted a link to the cover of girlfriend – and Pillowtalk music video star – Gigi Hadid’s nude cover of Vogue France.
“Here’s the version where I’m wearing mostly Chanel N°5 ;)” she wrote on Instagram.
His emoji reply suggested he was more than a little enthralled by the arty black and white shot.
In the US chart, he pushed Justin Bieber down to two and three with Love Yourself and Sorry respectively.
Zayn will released his album Mind Of Mine on March 25, exactly one year after he left One Direction.